Journal of Medicine and Applied Clinical Sciences | Volume 1 Issue 1 | Pages: 4-6

Editorial Article

OPEN ACCESS | Published on : 31-Dec-2025

The Impact of Aging on HIV Acquisition in the Male Genital Tract

• Khalid Abdelsamea Mohamedahmed
• Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, Jerash University, Jerash, Jordan.; Department of Hematology and Immunohematology, Faculty of Medical Laboratory Sciences, University of Gezira, Wad Medani, Sudan.; Department of Immunology, Faculty of Medical Laboratory Sciences, University of Gezira, Wad Medani, Sudan.

Abstract

Ageing is associated with progressive hormonal, immunological, and structural changes in the male reproductive system, including declining testosterone levels and deterioration of semen parameters. At the same time, the proportion of older men living with human immunodeficiency virus (HIV) is increasing globally. This mini-review summarizes current evidence on the interaction between ageing and HIV within the male genital tract, with emphasis on semen quality, immune status, and fertility implications. Available data indicate that while semen parameters may remain near normal in asymptomatic HIV-positive men, advancing age and disease progression are associated with reduced sperm motility, abnormal morphology, and impaired reproductive potential, particularly in the context of low CD4 cell counts. Understanding the combined effects of ageing and HIV is essential for improving reproductive health counseling and clinical management in older HIV-infected men.

Keywords

HA1C, Diabetes mellitus, Diagnostic biomarker, Prognostic biomarker

References

• Ajayi AF, Onaolapo MC, Omole AI, Adeyemi WJ, Oluwole DT. (2023). Mechanism associated with changes in male reproductive functions during ageing process. Exp Gerontol. 179:112232. doi: 10.1016/j.exger.2023.112232.

  Kaufman J-M, Lapauw B, Mahmoud A, T’Sjoen G, Huhtaniemi IT. (2019). Aging and the Male Reproductive System. Endocrine Reviews. 40(4):906-972. doi: 10.1210/er.2018-00178.

  Kaufman JM, Vermeulen A. (2025). The decline of androgen levels in elderly men and its clinical and therapeutic implications. Endocr Rev. 26(6):833-76. doi: 10.1210/er.2004-0013.

  Keerthan S, Ramakrishnan V. (2018). Effects of HIV Infection and its Association with Male Infertility. ARC Journal of AIDS. (2):18-21.

  Jaqua E, Labib W, Danji K. (2022). HIV-Associated Conditions in Older Adults. Cureus. 18;14(12): e32661. doi: 10.7759/cureus.32661 doi: 10.7759/cureus.32661.

  Maina WK, Kim AA, Rutherford GW, Harper M, K'Oyugi BO, Sharif S, et al. (2014). Kenya AIDS Indicator Surveys 2007 and 2012: implications for public health policies for HIV prevention and treatment. J Acquir Immune Defic Syndr. 66 Suppl 1(Suppl 1): S130-7. doi: 10.1097/QAI.0000000000000123.

  Mohamed OO, Mohamedahmed KA, Barakat ME, et al. (2025). Abdalla. Assessment of viral load and liver enzymes levels among infected individuals with hepatitis B virus in Kassala State, Sudan. Journal of Medical Surgical and Allied Sciences. 2025;3(2):8-14. doi: 10.37446/jmedsurg/rsa/3.2.2025.8-14.

  Schumacher B, Pothof J, Vijg J, Hoeijmakers JHJ. (2021). The central role of DNA damage in the ageing process. Nature. 592(7856):695-703. doi: 10.1038/s41586-021-03307-7.

  Shisana O, Rehle T, Zuma K, Simbaya LC, Jooste S, Pillay-van-Wyk V et al. (2012). South African national HIV prevalence, incidence and behaviour survey. Summary presented to the 6th South African AIDS Conference, Durban. 2013.

  Stone BA, Alex A, Werlin LB, Marrs RP. (2013). Age thresholds for changes in semen parameters in men. Fertil Steril. 100(4):952-958. doi: 10.1016/j.fertnstert.2013.05.046.

  Vandermaelen A, Englert Y. (2010). Human immunodeficiency virus serodiscordant couples on highly active antiretroviral therapies with undetectable viral load: conception by unprotected sexual intercourse or by assisted reproduction techniques? Hum Reprod. 25(2):374-379. doi: 10.1093/humrep/dep412.

  von Humboldt S, Leal I. (2014). Adjustment to Aging in Late Adulthood: A Systematic Review. International Journal of Gerontology. 8(3):108-113. doi: 10.1016/j.ijge.2014.03.003.

  Bhasin S, Valderrábano RJ, Gagliano-Jucá T. (2022). Age-Related Changes in the Male Reproductive System. In: Feingold KR, Anawalt B, Blackman MR, etal, editors. Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc.; 2000–. PMID: 25905229.